Table 1.

Effect of NFκB inhibitors (and control drugs) on endothelial TF expression in the NYIDD sickle mouse^*

Condition or Agent	n	TF expression (%)	P#
NY1DD at ambient air	10	12.8 ± 2.9
NY1DD post-HR	27	34.7 ± 6.3	<0.001
+ andrographolide	6	18.0 ± 2.1	<0.001
+ curcumin	10	23.2 ± 7.3	<0.001
+ didox	6	14.3 ± 2.3	<0.001
+ trimidox	12	17.5 ±6.9	<0.001
+ isohelenin	5	10.8 ± 3.0	<0.001
+ sulfasalazine	5	25.2 ± 3.0	<0.05
+ salsalate	6	29.3 ± 5.7	ns
+ 4H-andrographolide§	6	31.3 ±2.1	ns
+ hydroxyurea§	6	35.6 ± 4.8	ns

^*TF is expressed as percentage of pulmonary veins being TF positive, and data are shown as mean ± SD.

^#Post-H/R is compared to ambient air; all others are compared to post-HR with vehicle but without the active drug.

^§These agents are control drugs; all others are known NFκB inhibitors.