Figure 2.

Published target mRNAs and functional role of disease related microRNAs in cardiomyocytes and fibroblasts. Targets that could not be validated in later publications are labeled with a (?). The arrow adjacent to miRNA illustrates whether the miRNA is up or downregulated in cardiac disease. Green and purple shaded regions indicate stimulation or repression of a process in cardiac disease, respectively. AP-1, activator protein 1; CDC42, cell division cycle 42; CTGF, connective tissue growth factor; Cx43, connexin 43; Hand2, heart and neural crest derivatives expressed 2; HCN2, hyperpolarization activated cyclic nucleotide-gated potassium channel 2; HIF1α, Hypoxia inducible factor; Hop, homeodomain-only protein; Hsp, heat shock protein; Irx5, Iroquois homeobox protein 5; Kcnd2, potassium voltage-gated channel subfamily D member 2; Kcnj2, potassium inwardly-rectifying channel, subfamily J, member 2; MEF2, myocyte enhancing factor-2; MuRF 1, muscle RING-finger protein 1; PDCD4, programmed cell death 4; PHD2, prolyl hydroxylase 2; PP2A, B56a regulatory subunit of protein phosphatase 2a; PTEN, phosphatase and tissue homolog; RhoA, Ras homolog gene family, member A; Sirt1, Sirtuin; SRF, serum response factor; Thrap1, thyroid hormone receptor associated protein1