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Model of the mechanism by which zebrafish PGE2 negatively regulates E-cadherin via a Snai1a-dependent mechanism. Following EP4 receptor engagement by PGE2, the Gβγ subunits bind Gsk3β, preventing it from inhibiting Snai1a by phosphorylation. Ubiquitylation of Snail is decreased, stabilizing Snai1a protein. Snai1a can then transcriptionally repress E-cadherin, altering the cell adhesion of signaling cells. Blue arrows, pathway mechanism following PGE2 signaling activation.
