Figure 5. TLR4 activation results in an elevation in TRIF signaling and subsequent IFN-β release by macrophage from UC patients.

Macrophages from UC (n = 11) and HC (n = 7) were stimulated for 6 h with rLPS (TLR4), Pam₃CSK₄ (TLR2/1) or Poly I:C (TLR3) and the levels of IFN-β release in determined. Results are expressed as relative luciferase activity (RLA) (mean ± SEM, ***p<0.001).