Figure 6.

Central metabolic flux map for BP10001 under different fermentation conditions. Substrates and extracellular products are shown in capital letters. Flux distributions were calculated for the batch fermentation using xylose alone (numbers on top) as well as for fed-batch fermentations using glucose-xylose (numbers in italic; middle) and glucose alone (numbers in bold; bottom). The data used in FBA are from Additional file 3. Objective functions and unrestricted product release rates are underlined twice and once, respectively. Flux distributions were calculated for the assumption that q_NADPH for xylose reduction = q_xylitol (left in row) or for the upper (middle in row) and lower (right in row) limits of NADPH utilization by XR. Only the relevant part of the central carbon metabolism is displayed for reasons of clarity. Flux values are given in mmol/g CDW/h and values for biomass are displayed in gram.