Table 1.
Results of sensitivity analysis (N94 and N99 shows the size of the cohorts of respective years)
Females | Males | |||||||
---|---|---|---|---|---|---|---|---|
N94,N99 | log-rank | Median (years) | N94,N99 | log-rank | Median (years) | |||
94–96 | 99–01 | 94–96 | 99–01 | |||||
Base calculation | 261,206 | 0.0009 | 0.64 | 0.29 | 142,115 | 0.8132 | 0.39 | 0.17 |
1. Approaches to identification of recovery events | ||||||||
Time to recovery (1.5 years) | 237,192 | 0.0049 | 1.05 | 0.36 | 135,109 | 0.9988 | 0.69 | 0.41 |
Time to recovery (0.5 years) | 286,223 | 0.0043 | 0.34 | 0.21 | 155,129 | 0.9686 | 0.24 | 0.17 |
Alzheimer’s disease and dementia | 261,206 | 0.0178 | 0.61 | 0.41 | 142,115 | 0.4345 | 0.42 | 0.17 |
2. Approaches to identification of incident cases | ||||||||
All Medicare sources used | 286,221 | 0.0013 | 0.64 | 0.31 | 159,125 | 0.6977 | 0.39 | 0.24 |
Keeping not only primary diagnoses | 323,269 | 0.0009 | 0.49 | 0.24 | 182,145 | 0.4876 | 0.36 | 0.09 |
No requirement of second visit | 523,416 | 0.0111 | 0.09 | 0.05 | 276,242 | 0.4220 | 0.05 | 0.01 |
Acceptable lag of pre-diagn.=0.5year | 261,206 | 0.0009 | 0.64 | 0.29 | 146,117 | 0.8363 | 0.39 | 0.20 |
Only 436 ICD-9 code included | 228,182 | 0.0017 | 0.61 | 0.25 | 123,90 | 0.8276 | 0.39 | 0.24 |
Exclude hemorrhagic (ie, 431) stroke | 258,202 | 0.0016 | 0.62 | 0.29 | 141,109 | 0.7406 | 0.39 | 0.25 |
Only hemorrhagic (i.e., 431) stroke | 13,14 | 0.5680 | 0.016 | 0.063 | 10,12 | 0.1711 | 0.227 | 0.027 |
Include ICDs: 430–432 | 23,28 | 0.0871 | 0.112 | 0.067 | 20,20 | 0.6478 | 0.153 | 0.114 |
Exclude not completely covered | 229,188 | 0.0041 | 0.61 | 0.27 | 136,108 | 0.5108 | 0.39 | 0.14 |
3. Factors of observed heterogeneity | ||||||||
65≤Age≤72 | 56,43 | 0.0140 | 0.61 | 0.21 | 31,31 | 0.4543 | 0.25 | 0.32 |
73≤Age≤84 | 139,110 | 0.0096 | 0.72 | 0.30 | 95,66 | 0.8493 | 0.39 | 0.20 |
85≤Age | 66,53 | 0.4828 | 0.61 | 0.46 | 16,18 | 0.3374 | 0.15 | 0.09 |
Charlson Index=0 | 107,77 | 0.0522 | 0.61 | 0.24 | 55,36 | 0.9565 | 0.18 | 0.23 |
1≤Charlson Index≤3 | 120,95 | 0.0232 | 0.76 | 0.36 | 66,56 | 0.7897 | 0.46 | 0.14 |
Charlson Index≥4 | 34,34 | 0.1317 | 0.61 | 0.25 | 21,23 | 0.8836 | 0.79 | 0.25 |
Disability group=1 | 143,128 | 0.0007 | 0.60 | 0.24 | 97,87 | 0.4733 | 0.39 | 0.13 |
Disability group=2 | 47,27 | 0.0504 | 1.01 | 0.21 | 22,13 | 0.4767 | 0.13 | 0.28 |
Disability group=3 | 71,51 | 0.9775 | 0.80 | 0.90 | 23,15 | 0.5246 | 1.32 | 1.49 |
4. Censoring strategies | ||||||||
Cases of death are recovery cases | 261,206 | 0.0059 | 0.50 | 0.25 | 142,115 | 0.4704 | 0.39 | 0.16 |
Cases of death are never recovered | 346,278 | 0.0478 | 2.61 | 0.93 | 194,154 | 0.5400 | 1.20 | 1.17 |
5. Disenrollment from Medicare and coverage by HMO | ||||||||
All covered by HMO are included | 284,215 | 0.0125 | 0.61 | 0.33 | 149,124 | 0.8593 | 0.37 | 0.17 |
Fraction of HMO enrollment≤0.3 | 264,209 | 0.0015 | 0.62 | 0.31 | 145,118 | 0.9811 | 0.39 | 0.17 |
6. Study Design effect | ||||||||
Using NLTCS weights | 472524, 427500 | 0.62 | 0.31 | 270628, 255493 | 0.39 | 0.13 |