Table 1.
Descriptive statistics for participant rating, psychomotor, and attention outcomes as a function of dose.
| Placebo | TRZ 0.125 mg/70kg | TRZ 0.25 mg/70kg | ALC 0.40 g/kg | ALC 0.80 g/kg | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Mean | (SE) | Mean | (SE) | Mean | (SE) | Mean | (SE) | Mean | (SE) | |
| Participant rating | ||||||||||
| Drug Strength | 1.25 | (0.24) | 1.40 | (0.31) | 2.45* | (0.18) | 2.55*† | (0.01) | 3.45*† | (0.11) |
| Psychomotor | ||||||||||
| Circular Lights (number correct) | 92.45 | (1.59) | 87.83 | (2.66) | 80.46* | (2.11) | 90.94 | (1.47) | 80.99* | (2.49) |
| Balance (seconds) | 70.77 | (6.74) | 72.09 | (15.87) | 30.25* | (4.20) | 65.43 | (6.71) | 36.06* | (6.53) |
| Attention | ||||||||||
| DSST | ||||||||||
| Attempted | 95.46 | (2.57) | 88.32*† | (2.31) | 79.89* | (2.46) | 97.92 | (1.41) | 82.71* | (2.24) |
| Proportion correct | 93.89 | (1.38) | 94.42 | (1.40) | 92.97 | (3.09) | 94.30 | (1.07) | 87.82* | (1.71) |
| Choice reaction time task | ||||||||||
| Median RT | 83.54 | (22.10) | 124.79 | (19.05) | 241.25* | (23.68) | 56.25 | (15.83) | 261.67* | (42.60) |
| Proportion correct | −0.04 | (0.02) | −0.07 | (0.01) | −0.13* | (0.02) | −0.07 | (0.01) | −0.10* | (0.02) |
| Proportion incorrect | 0.03 | (0.01) | 0.05 | (0.01) | 0.08* | (0.01) | 0.06 | (0.01) | 0.08* | (0.01) |
| Proportion timeouts (2 sec) | 0.05 | (0.03) | 0.05 | (0.02) | 0.13* | (0.03) | 0.03 | (0.01) | 0.09 | (0.02) |
| Proportion timeouts (6 sec) | 0.00 | (0.00) | 0.00 | (0.00) | 0.01 | (0.01) | 0.00 | (0.00) | 0.00 | (0.00) |
| Error detection accuracy (2 sec) | −0.06 | (0.03) | −0.06 | (0.02) | −0.19* | (0.03) | −0.06 | (0.02) | −0.12 | (0.02) |
| Error detection accuracy (6 sec) | −0.02 | (0.02) | −0.05 | (0.02) | −0.09* | (0.02) | −0.08 | (0.02) | −0.08 | (0.02) |
| Divided attention | ||||||||||
| Tracking moves | 98.59 | (1.83) | 95.87 | (2.37) | 87.18*† | (2.38) | 95.77 | (1.97) | 96.46 | (1.45) |
| Tracking deviation | 115.46 | (6.93) | 137.79 | (14.04) | 147.23*† | (10.03) | 111.71 | (5.25) | 123.88 | (5.55) |
| Tracking overlap | 94.98 | (2.72) | 87.81 | (3.46) | 78.06*† | (3.47) | 95.55 | (2.31) | 89.45 | (2.71) |
| Total responses (monitoring) | 93.60 | (1.86) | 92.66 | (2.39) | 86.06 | (4.96) | 93.91 | (2.47) | 92.62 | (2.51) |
| Mean RT (monitoring) | 119.38 | (5.10) | 133.98† | (6.60) | 127.53 | (7.39) | 109.31 | (6.83) | 132.05 | (4.27) |
| Proportion correct (monitoring) | 91.34 | (2.11) | 87.74 | (2.84) | 82.20*† | (4.49) | 95.04 | (2.47) | 91.31 | (2.34) |
Data are either peak raw values (participant rating), peak percentage of predrug values (psychomotor, DSST, and divided attention) or difference from predrug values (choice reaction time).
*
indicates a significant difference between active drug and placebo (p ≤0.05).
†
indicates a significant difference between alcohol and triazolam at corresponding dose level (p ≤0.05).