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. Author manuscript; available in PMC: 2011 Mar 1.
Published in final edited form as: Semin Nephrol. 2010 Mar;30(2):126–140. doi: 10.1016/j.semnephrol.2010.01.004

Table 2.

Summary of Studies Using the GoKinD DNA Collection

Reference Study Design GoKinD Sample
SubSets		 Chr. SNP Nearest
Gene(s)		 P-value
Ma et al. 200742 Case-control,
candidate gene,
1 SNP		 Cases (N=577) and
controls (N =597)		 7p15 rs16139 NPY 0.48
Millis et al. 200736 Case-control,
candidate gene,
24 SNPs		 Cases (N=531) and
controls (N =564)		 8q24 rs11993333
rs13447075
rs2648862		 PVT1 0.02*
3.0×10−3*
8.0×10−3*
Ma et al. 200838 Case-control,
candidate gene,
2 SNPs		 Cases (N=662) and
controls (N =620)		 19p13 rs1799969
rs5498† 		ICAM-1 0.58
0.11 (genotypes: P=0.01
among females)
Tong et al. 200837 Case-control,
candidate gene,
1 SNP		 Cases (N=865) and
controls (N =574)‡ 		7q22 rs1617640 EPO 2.66×10−8
Zhang et al. 200941 Case-control,
candidate gene,
3 SNPs		 Cases (N=578) and
controls (N =599)		 3q27 rs16861194
rs17300539
rs266729		 ADIPOQ 0.49
0.88
Males: 0.46, Females: 0.02
Greene et al.
200839 		Case-control,
GWA scan,
Affymetrix 10K		 DR3/4 cases (N=112)
and controls (N =148)		 2p22 rs1368086
rs725238
rs11886047		 PLEKHH2 2.1×10−5
8.9×10−4
3.4×10−3 (genotypes: 601
cases and 577 controls)
Gu et al. 200843 Case-control,
candidate gene		 Cases (N=663) and
controls (N =622)		 5p12 GHRd3
(genomic
deletion of
exon 3)		 GHR 0.97
Zhang et al. 200940 Case-control,
candidate gene,
7 SNPs		 Cases (N=578) and
controls (N =599)		 3q22-24 rs953239
rs7638459
rs17624218
rs7621642
rs2033912
rs3821647
rs7610200		 TRPC1 n.s
n.s
n.s
Males: 0.66, Females: 0.05
Males: 0.69, Females: 0.05
Males: 0.95, Females: 0.10
n.s

Chr. = chromosome, n.s = not significant

*

Utilized logistic regression under and additive model and adjusted for effects of age2 (age X age), age3 (age X age X age), diabetes duration, and cigarette smoking status.

†

Ma et al. reported that rs5498 had a high heterozygous index and note that the difference of heterozygous frequencies between DN cases and controls achieved borderline significance (P=0.052). Also observed a gender-specific effect of the genetic risk for DN.

‡

Controls (N=574) were limited to those without nephropathy and retinopathy.

Both rs1368086 and rs725238, as well as 15 other SNPs, were genotyped in 246 GoKinD case trios. TdT analysis of these SNPs revealed significant over-transmission of rs11886047 to case probands. rs11886047 was subsequently genotyped in all GoKinD case-control singletons (N=601 cases, N=577 controls): no difference in allele frequencies were observed. However, there was a difference among genotype frequencies (P = 3.4×10−3).