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A. Bax, Bak and Bim are sequestred by Bcl-2, Bcl-xL and Mcl-1 at the outer mitochondrial membrane. B. In response to ABT-737, Bax, Bak and Bim proteins are liberated from Bcl-2 and Bcl-xL but not from Mcl-1L. Thus Bim can directly enhance Bax and Bak oligomerization triggering MOMP formation (C) and release of pro-apoptotic proteins such as cytochrome c in the cytosol.
