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. Author manuscript; available in PMC: 2010 Mar 30.
Published in final edited form as: Alcohol Clin Exp Res. 2008 Jun 28;32(8):1408–1416. doi: 10.1111/j.1530-0277.2008.00718.x

Table 1. Effects of FIN on general intake measures and bout dynamics during FIN treatment, early withdrawal, and late withdrawal phases.

All values represent the mean ± SEM of each treatment phase for n = 7 VEH-treated mice, n = 8 FIN-50 mice, and n = 8 FIN-100 mice.


Experimental Phase

FIN
Treatment
Early
Withdrawal
Late
Withdrawal

10E Licks
  VEH 445 ± 107 698 ± 196 796 ± 180
  FIN-50 207 ± 91* 396 ± 163 531 ± 160
  FIN-100 97 ± 29** 344 ± 166 399 ± 173
10E Preference Ratio
  VEH 0.84 ± 0.05 0.87 ± 0.04 0.94 ± 0.01
  FIN-50 0.48 ± 0.09*** 0.65 ± 0.13 0.83 ± 0.08
  FIN-100 0.41 ± 0.05*** 0.70 ± 0.07 0.77 ± 0.10
Total Fluid Intake (licks/2-hr)
  VEH 529 ± 127 821 ± 229 837 ± 186
  FIN-50 360 ± 139 513 ± 160 578 ± 166
  FIN-100 230 ± 81 432 ± 193 465 ± 176
Inter-Session Water Intake (ml/22-hr)
  VEH 5.08 ± 0.25 4.92 ± 0.26 5.07 ± 0.24
  FIN-50 5.46 ± 0.03 5.23 ± 0.38 5.32 ± 0.33
  FIN-100 6.08 ± 0.29 5.62 ± 0.34 5.45 ± 0.31

Bout Frequency
  VEH 6.1 ± 1.2 7.5 ± 1.8 8.3 ± 1.5
  FIN-50 2.6 ± 1.1* 4.4 ± 1.8 5.5 ± 1.7
  FIN-100 1.3 ± 0.3** 3.6 ± 1.5 3.7 ± 1.5
Bout Size (licks)
  VEH 62.4 ± 8.0 85.0 ± 8.6 88.8 ± 13.9
  FIN-50 51.7 ± 7.4 87.4 ± 10.0 95.0 ± 13.9
  FIN-100 67.3 ± 10.1 85.6 ± 10.5 104.9 ± 15.3
*

P ≤ 0.05,

**

P ≤ 0.01

***

P ≤ 0.001 versus VEH group.