Table 1.
Baseline characteristics
| All | EXT-WMHIV = 0 | EXT-WMHIV = 1 | p | BI = 0 | BI = 1 | p | |
|---|---|---|---|---|---|---|---|
| N | 2229 | 1912 | 313 | 1975 | 253 | ||
| Age (mean±SD) | 62±9 | 62±9 | 63±9 | 0.030 | 62±9 | 65±9 | <0.001 |
| Women, n (%) | 1179 (53) | 911 (48) | 139 (44) | 0.288 | 923 (47) | 126 (50) | 0.357 |
| High-school graduate | 2149 (97) | 1842 (96) | 303 (97) | 0.745 | 1907 (97) | 241 (95) | 0.255 |
| Hypertension | 916 (42) | 779 (41) | 136 (47) | 0.048 | 770 (40) | 146 (58) | <0.001 |
| Active smokers | 267 (12) | 226 (12) | 41 (14) | 0.261 | 234 (12) | 33 (13) | 0.661 |
| Diabetes | 255 (127) | 214 (11) | 41 (14) | 0.151 | 215 (11) | 40 (16) | 0.028 |
| Prevalent stroke | 38 (2) | 25 (1) | 13 (4) | <0.001 | 17 (0.9) | 21 (8) | <0.001 |
| Prevalent dementia | 6 (0.3) | 4 (0.2) | 2 (0.6) | 0.202 | 5 (0.3) | 1 (0.4) | 0.515 |
| Prevalent MCI | 534 (24) | 431 (23) | 103 (33) | <0.001 | 469 (24) | 66 (27) | 0.381 |
| Prevalent amnestic MCI | 283 (13) | 234 (12) | 49 (16) | 0.091 | 252 (13) | 31 (12) | 0.813 |
| log (WMHIV) | − 3.0±1.0 | − 3.2±0.9 | − 1.4±0.9 | <0.001 | − 31±1.0 | − 2.5±1.2 | <0.001 |
| EXT-WMHIV | 313 (14) | - | - | - | 242 (12) | 70 (28) | <0.001 |
| BI | 253 (11) | 183 (10) | 70 (22) | <0.001 | - | - | - |
MCI: Mild Cognitive Impairment; WMHV: White Matter Hyperintensity Volume; EXT-WMHV: Extensive WMHV; BI: MRI-defined Brain Infarcts; 0: Absent; 1: Present