Table 3.

Association of WMHV, EXT-WMHV and BI with incident MCI

		Odds ratio (95% confidence interval) for incident
		MCI	p	amnestic MCI	P
N events / sample size		93 / 1134		93 / 1344
WMHV	Model 1	1.06 (0.83–1.36)	0.617	1.24 (0.98–1.58)	0.071
	Model 2	1.06 (0.83–1.36)	0.635	1.24 (0.98–1.57)	0.071
	Model 3	1.04 (0.81–1.33)	0.750	1.22 (0.96–1.55)	0.102
	Model 4	1.09 (0.85–1.39)	0.516	1.22 (0.96–1.56)	0.100
EXT-WMHV	Model 1	1.27 (0.68–2.40)	0.452	1.70 (0.97–2.97)	0.062
	Model 2	1.26 (0.67–2.39)	0.471	1.67 (0.96–2.93)	0.072
	Model 3	1.13 (0.59–2.17)	0.719	1.65 (0.94–2.92)	0.084
	Model 4	1.35 (0.71–2.56)	0.363	1.64 (0.93–2.89)	0.087
BI	Model 1	0.76 (0.37–1.57)	0.456	1.39 (0.77–2.52)	0.277
	Model 2	0.77 (0.37–1.59)	0.478	1.39 (0.77–2.52)	0.278
	Model 3	0.68 (0.31–1.45)	0.314	1.24 (0.65–2.38)	0.511
	Model 4	0.73 (0.35–1.52)	0.400	1.26 (0.69–2.31)	0.452

WMHV: natural log from ratio of WMHV volume over total intracranial volume; EXT-WMHV: extensive WMHV; BI: MRI-defined brain infarcts; MCI: mild cognitive impairment; Model 1: logistic regression adjusted for age, sex, education, interval between exams; Model 2: Model 1 additionally adjusted for systolic blood pressure, current smoking, diabetes, history of cerebrovascular disease; Model 3: Model 1 additionally adjusted for interim stroke, after excluding participants with prevalent stroke at baseline; Model 4: Model 1 additionally adjusted for BI^* or WMHV^†