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. Author manuscript; available in PMC: 2011 Mar 3.
Published in final edited form as: Cell Metab. 2010 Mar 3;11(3):206–212. doi: 10.1016/j.cmet.2010.02.001

Figure 4. Schematic Representation of the Regulation of FGF21 Gene Expression and FGF21 Effects during the Transition from Fetal to Neonatal Metabolism.

Figure 4

Transcription of the FGF21 gene in the liver and release of FGF21 into the circulation are induced immediately after birth in response to the high fatty acid availability associated with the initiation of suckling. PPARα mediates the milk ingestion-dependent induction of FGF21 expression at birth. The burst in FGF21 levels after birth exerts endocrine actions that are relevant to metabolic adaptations in the neonatal period, mainly the induction of thermogenesis in BAT.