Figure 3.

Hyper-aDMRs are not associated with housekeeping genes, but are enriched for neural-specific genes. (A) Probes were classified as “housekeeping” (HK) (lying within 2.5 kb of the TSS of a housekeeping gene according to Eisenberg and Levanon 2003) or otherwise. All probes with a positive methylation/age correlation were ranked in order of increasing P-value (i.e., decreasing probability of being a bona fide aDMR). For successively larger sets of probes from the top of the ranked list, we calculated the fraction of probes contained in the housekeeping set. (B) We subdivided CpG sites and indentified a brain-specific subset (lying within 2.5 kb of the TSS of a nervous system gene according to Dorus et al. 2004). Subsequent analysis is as for A. The filled regions indicate 95% credible intervals estimated from a Beta model.