Figure 5.

Hyper-aDMRs are also hypermethylated in human leukaemia. We identified subsets of CpG sites as overlapping promoters (TSS ± 2.5 kb) of genes associated with leukemia according to Figueroa et al. (2009). For each of the two disease types, we calculated the enrichment of hyper-aDMRs amongst disease-associated CpGs relative to a model whereby aDMRs and disease genes occur independently. Boxes indicate 50% credible intervals on our estimate of this ratio, and whiskers indicate 95% intervals (Beta model).