Figure 6.

Hyper-aDMRs replicate in buccal cells. For each probe with a significant positive aging-methylation correlation in the whole-blood data (P < 0.01), we calculated Spearman's ρ-values from the buccal data set. We split these into reproduced (correlation in the same direction in the CD4⁺ and CD14⁺ data sets) and nonreproduced data sets, and also show results for the complete set. We plot 50% and 95% credible intervals for the box-and-whisker plots on bootstrap estimates of the mean for each data set.