Figure 4.

(A) Dependence of chromatin compaction with replication timing. Compaction data were from Gilbert et al. (2004). Variation of global non-CpG substitution rate (B) and CpG substitution rate (C) with replication timing after controlling for chromatin compaction. Timing values and substitution rates are determined within all genomic regions for which chromatin compaction was determined (Gilbert et al. 2004). (Black) Log₂(Open:Input) ≤ −1; (blue) −1 < log₂(Open:Input) ≤ 0; (orange) 0 < log₂(Open:Input) ≤ 1; (red) log₂(Open:Input) > 1. The window size is as defined in Gilbert et al. (2004) (mean size: 146 kb).