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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: J Immunol. 2009 Oct 14;183(9):5468–5476. doi: 10.4049/jimmunol.0902344

Figure 1. Reduction in bone marrow B cells in Mb1-Cre ShcFFF mice.

Figure 1

(A) Schematic of bone marrow B cell development showing early expression of Mb1-Cre in the common lymphoid progenitor (CLP) stage and later expression of Cd19-Cre within the pro-B stage. (B) Expression of ShcFFF in marrow and spleen. CD19+ cells were positively selected from bone marrow and spleen of the indicated mice, immunoprecipitated with anti-FLAG, and immunoblotted with anti-Shc antibody to detect ShcFFF transgenic protein. ShcFFF is visible in both bone marrow and spleen of Mb1-Cre/ShcFFF mice, but only in the spleen of Cd19-Cre/ShcFFF mice. Non-specific band, N.S.