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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: J Immunol. 2009 Oct 14;183(9):5468–5476. doi: 10.4049/jimmunol.0902344

Figure 2. Shc is required during early B cell development prior to the pro-B transition.

Figure 2

(A) Absolute numbers of B lineage cells in bone marrow. Conditional expression of ShcFFF with Mb1-Cre shows an initial developmental block from the CLP to Pro-B stage. (B) Mb1-Cre/ShcWT mice do not show a defect in B cell numbers in the bone marrow. (C) Conditional expression of ShcFFF during later stages of development with Cd19-Cre does not affect lymphocyte numbers in the bone marrow. (D) Detailed analysis of early subsets from Mb1-Cre/ShcFFF mice reveals an initial defect in cell numbers at the pre-pro-B to pro-B transition that is not present in Mb1-Cre/ShcWT mice. *P<0.05, **P<0.01.