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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: J Immunol. 2009 Oct 14;183(9):5468–5476. doi: 10.4049/jimmunol.0902344

Figure 4. ShcFFF expression impairs response of pro-B cells to IL-7 although IL-7 receptor is present.

Figure 4

(A) (left) Normal expression pattern of the IL-7 receptor during early B cell development. (right) Comparable expression of IL-7 receptor in Mb1-Cre and Mb1-Cre/ShcFFF littermates in the early B cell subsets. (B) Sorted pro-B cells were cultured with the indicated concentration of IL-7. On the fourth day after plating, cells were pulsed with 1μCi of [3H] thymidine for eight hours, and thymidine incorporation was determined. *P<0.01, **P<0.001, ***P<0.0001.