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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: J Immunol. 2009 Oct 14;183(9):5468–5476. doi: 10.4049/jimmunol.0902344

Table 1.

Renewal and Production Rates of Bone Marrow B Cell Subsets

Mb1-Cre Mb1-Cre ShcFFF
Pro Renewal Rate
(% of pool/day)		 18.5 18.4
Production Rate
(cells/day *103)		 81.3 37.3
Pre Renewal Rate
(% of pool/day)		 19.6 20.5
Production Rate
(cells/day *103)		 389.02 54.016

Percentages of BrdU+ Pro-B and Pre-B cells for each mouse were determined by flow cytometry and multiplied by total bone marrow cell counts (trypan) from two femurs of each mouse to obtain total BrdU+ cell numbers. The regression coefficients of percent and absolute BrdU labeling versus time provide an estimate of renewal and production rates, respectively.