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. Author manuscript; available in PMC: 2010 Mar 31.
Published in final edited form as: Int J Immunopathol Pharmacol. 2009 Apr–Jun;22(2):311–322. doi: 10.1177/039463200902200208

Table 4.

The three tier expression status of inflammasome types in tissues

Inflammasome type Tissue
First tier (“ready to go” expression status with all components)
    NALP1 inflammasome (NALP1, PYCARD, caspase-1 and caspase-5) Brain, placenta
    NALP3 inflammasome (NALP3, PYCARD and caspase-1, Cardinal ) Blood, brain
    IPAF inflammasome (IPAF, NAIP, caspase-1) Blood, Thymus
Second tier (nearly-ready expression status that requires one component missing)
    NALP1 inflammasome Blood, pancreas, placenta, trachea
    NALP3 inflammasome Vascular, lymph nodes, pancreas, placenta, thymus, trachea
    IPAF inflammasome Brain, lymph node, pancreas, placenta, spleen
Third tier (expression status that requires upregulation of more than one components)
    NALP1 inflammasome Bone marrow, vascular, heart, spleen, thymus
    NALP3 inflammasome Bone marrow, heart, spleen, trachea
    IPAF inflammasome Bone marrow, vascular, heart, placenta, trachea