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. Author manuscript; available in PMC: 2011 Mar 2.
Published in final edited form as: Vaccine. 2010 Jan 4;28(10):2236–2242. doi: 10.1016/j.vaccine.2009.12.049

Table 2.

Systemic Reactogenicity

1st Vaccination 2nd Vaccination
Total Grade 1 Grade 2 Grade 3 Total Grade 1 Grade 2 Grade 3
5 μg
Fever 0 0 0 0 0 0 0 0
Headache 3/12 1 2 0 5/11 4 1 0
Nausea/vomiting 0 0 0 0 0 0 0 0
Myalgia 0 0 0 0 0 0 0 0
Malaise 3/12 3 0 0 1/11 0 0 1
Tiredness 2/12 1 1 0 1/11 1 0 0
Arthralgia 0 0 0 0 0 0 0 0
20 μg
Fever 0 0 0 0 1/9 0 1 0
Headache 7/12 5 2 0 1/9 1 0 0
Nausea/vomiting 1/12 1 0 0 0 0 0 0
Myalgia 0 0 0 0 0 0 0 0
Malaise 2/12 1 1 0 1/9 0 1 0
Tiredness 4/12 3 1 0 0 0 0 0
Arthalgia 0 0 0 0 0 0 0 0
80 μg
Fever 0 0 0 0 NA
Headache 2/4 2 0 0 NA
Nausea/vomiting 0 0 0 0 NA
Myalgia 1/4 1 0 0 NA
Malaise 0 0 0 0 NA
Tiredness 0 0 0 0 NA
Arthralgia 1/4 1 0 0 NA

Maximum observed grade for each volunteer after each vaccination