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. 2010 Apr;135(4):321–331. doi: 10.1085/jgp.200910384

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© 2010 Purohit and Auerbach

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Figure 8. — Effect of Phe substitutions on R versus R* ACh binding energy. The y axis is the net change in the R versus R* ACh binding free energy (= 0.59 ln [(K_d/J_d)^mut/(K_d/J_d)^wt]; Table S5). The mutations αY190F and αW149F cause the biggest drop in the net binding energy.