Figure 12.

Pre-applications of antidepressants reduced ATP-evoked responses recorded from activated C8-B4 cells. (A) Representative traces and summary data for the effect of antidepressants (at the concentrations shown) on 100-µM ATP-evoked currents recorded from activated C8-B4 cells (+LPS). All of the antidepressants resulted in a statistically significant reduction in the ATP-evoked responses. For these experiments, the antidepressants were applied with the LPS that is required to trigger C8-B4 cell activation (see Results). The average data shown in the bar graph are from six to eight cells. (B) Summary bar graph for experiments as shown in A, but for different concentrations for the antidepressants, as shown in the figure. All of the drugs produced a significant reduction in ATP-evoked currents at 500 nM. The bars represent mean data from five to nine cells. All of the ATP-evoked currents were measured at a holding voltage of −60 mV.