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. 2010 Apr;135(4):367–378. doi: 10.1085/jgp.200910337

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© 2010 Antolin et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 2. — The Ca²⁺-activated Cl⁻ conductance represents the major component of the olfactory receptor current. An isolated ORN was stimulated for 1 s with (A) 500 µM IBMX and with (B) 500 µM IBMX and 2 mM niflumic acid. Gray bars denote the command for the presentation of the IBMX stimulus. (C) The peak receptor current amplitude evoked by IBMX was reduced by ∼94% relative to the control response when niflumic acid was present during stimulus presentation (n = 15). Consequently, the cationic current through CNG channels represents only a very small fraction of the total receptor current (∼6%). Error bars represent SEM.