Figure 1. Representative in vivo and ex vivo μCT images demonstrate cortical thickening induced by prostate cancer involving bone.

Sagittal in vivo longitudinal μCT scans obtained at 91 µm voxel size before and 10 weeks after (A) intrafemoral injection of vehicle control (left images) or MDA-PCa-2b human prostate cancer cells (right images) show cortical thickening (arrow) in the femora containing tumors. Ex vivo specimen μCT scans of excised femora at voxel sizes of 31-µm (B), 16-µm (C), and 8-µm (D) also show cortical thickening of the right femur with tumor. At the 8-µm voxel size, only the distal aspect of the femur was covered by the scans.