Table 1. Comparison of the replication accuracy and rate for NoV and HCV RdRps.
| RdRpa | Derivative Strain | Kcat (s−1) | Mutation Rate | Rate of Evolution | Uc (subs/genome) | |||
| in vitro nt subs/sited | sequence data nt subs/site/yr | |||||||
| Meand | SD | Meand | SD | Mean | SD | |||
| GII.4 2006b | NoV/Sydney696T/06/AU | 0.209 | 0.054 | 9.06×10−4 | 2.88×10−4 | 3.9×10−3 | 2.4×10−4 | 6.80 |
| rGII.4 | NoV/Sydney4264/06/AU | 0.168 | 0.024 | 8.34×10−4 | 2.56×10−4 | Not done | 6.26 | |
| GII.4 US95/96 | NoV/Sydney348/97/AU | 0.158 | 0.039 | 8.87×10−4 | 4.42×10−4 | 3.9×10−3 | 2.4×10−4 | 6.65 |
| GII.4 2006a | NoV/NZ327/06/AU | 0.183 | 0.024 | 5.54×10−4 | 3.84×10−4 | 3.9×10−3 | 2.4×10−4 | 4.16 |
| rGII.b | NoV/SydneyC14/02/AU | 0.155 | 0.093 | 1.53×10−4 | 1.22×10−4 | 2.4×10−3 | 4.9×10−4 | 1.15 |
| GII.7 | NoV/Mc17/02/Th | 0.238 | 0.088 | 2.21×10−5 | 4.58×10−4 | 2.3×10−3 | 1.5×10−4 | 0.17 |
| HCV/3a | HCV/VRL69 | 0.003 | 8.06×10−5 | 1.97×10−3 | 1.42×10−3 | Not done | 18.57 | |
| HCV/1b | HCV/VRL75 | 0.003 | 1.06×10−4 | 1.23×10−3 | 1.14×10−3 | 2.3×10−2 b | N/A | 11.57 |
a
The RdRps are named after their genotype except for the GII.4 pandemic strains which are named after their subcluster. Recombinants are indicated by an r before the genotype.
b
HVR1, published by Rispeter et al. [53].
c
U: Number of mutations per viral replication round.
d
The mean and standard deviation of a triplicate data set.