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Study Design. Abbreviations: BSC = best supportive care. aPemetrexed (500 mg/m2, day 1) plus cisplatin (75 mg/m2, day 1). bPemetrexed (500 mg/m2, day 1). cAfter completion of 4 cycles of induction treatment, eligible patients without disease progression will be randomized 2:1 to receive pemetrexed plus BSC or placebo plus BSC during the double-blind maintenance phase of the study.
