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Synthetic genetic analyses identified RSR1 as a CDC42-interacting gene. (A) Genetic interaction network representing synthetic lethal/sick interactions of cdc42-118 determined by SGA analysis. Genes are colored according to their YPD-defined cellular function. (B) Equivalent dilutions of rsr1Δ, cdc42, and rsr1Δ cdc42 mutants grown at 25, 30, and 34°C for 2d on SC-URA. The strains shown (left to right) are KKY 342, 343, 344, 345, 346, 297, and 298.
