Table 3.
Independent variables | All available subjects (n = 708) | Susceptible subpopulations | |
---|---|---|---|
HbA1c > 5.1% | T4 ≤ 8.5 μg/dl | ||
(n = 345) | (n = 344) | ||
Estimate (95% CI) | Estimate (95% CI) | Estimate (95% CI) | |
Intercept | 6.993 | 6.575 | 6.976 |
(6.296, 7.690)a | (5.525, 7.624)a | (5.929, 8.023)a | |
2,4-D, binary | 1.804 | 3.119 | 1.791 |
(0.410, 3.199)c | (0.958, 5.279)b | (-0.180, 3.761) | |
Log(HDL) for 2,4-D < LOD | -0.644 | -0.570 | -0.660 |
(-0.791, -0.497)a | (-0.798, -0.342)a | (-0.879, -0.440)a | |
Log(HDL) for 2,4-D ≥ LOD | -1.119 | -1.378 | -1.150 |
(-1.467, -0.771)a | (-1.908, -0.847)a | (-1.635, -0.664)a | |
Log (urinary creatinine) | -0.026 | -0.001 | 0.006 |
(-0.080, 0.028) | (-0.082, 0.081) | (-0.076, 0.088) | |
Gender | 0.034 | 0.004 | 0.006 |
(-0.043, 0.112) | (-0.111, 0.120) | (-0.114, 0.126) | |
Age (years) | 0.007 | 0.008 | 0.008 |
(0.004, 0.011)a | (0.003, 0.013)b | (0.003, 0.013)b | |
Non-Hispanic Black | -0.130 | -0.119 | -0.160 |
(-0.219, -0.041)b | (-0.255, 0.016) | (-0.292, -0.027)c | |
Mexican American | 0.079 | 0.130 | 0.099 |
(-0.014, 0.172) | (-0.016, 0.276) | (-0.053, 0.251) | |
Other ethnicity | 0.185 | 0.077 | 0.359 |
(-0.033, 0.402) | (-0.226, 0.380) | (0.040, 0.677)c | |
Past smoker | 0.019 | -0.012 | 0.040 |
(-0.079, 0.117) | (-0.154, 0.130) | (-0.104, 0.183) | |
Active smoker | 0.103 | 0.028 | 0.080 |
(0.022, 0.183)b | (-0.093, 0.148) | (-0.043, 0.202) | |
BMI 25-29 kg/m2 | 0.242 | 0.245 | 0.296 |
(0.159, 0.325)a | (0.117, 0.373)a | (0.173, 0.419)a | |
BMI ≥ 30 kg/m2 | 0.346 | 0.277 | 0.315 |
(0.248, 0.444)a | (0.140, 0.415)a | (0.162, 0.468)a | |
Alcohol consumption | 0.056 | 0.094 | 0.050 |
(-0.071, 0.184) | (-0.088, 0.275) | (-0.117, 0.217) | |
Income ≥ 20K (%) | -0.015 | 0.045 | 0.003 |
(-0.090, 0.060) | (-0.064, 0.154) | (-0.113, 0.119) | |
Hours of fasting | -0.014 | -0.013 | -0.020 |
(-0.022, -0.006)a | (-0.025, -0.001)c | (-0.032, -0.007)b |
a p ≤ 0.001, b p ≤ 0.01, c p ≤ 0.05
P-values for the interaction term log(HDL)*2,4-D are 0.01 for all subjects, 0.005 for subjects with HbA1c > 5.1%, and 0.06 for subjects with T4 ≤ 8.5 μg/dl.