Table 5.
Linear regression analysis of log(insulin) on 2,4-D and covariates for ages 20-59, NHANES III, 1988-1994.
| Independent variables | All available subjects (n = 703) | Susceptible subpopulations | |
|---|---|---|---|
| HbA1c > 5.1% | T4 ≤ 8.5 μg/dl | ||
| (n = 340) | (n = 342) | ||
| Estimate (95% CI) | Estimate (95% CI) | Estimate (95% CI) | |
| Intercept | 3.669 | 3.495 | 2.962 |
| (2.973, 4.364)a | (2.430, 4,560)a | (1.944, 3.980)a | |
| 2,4-D, binary | 0.763 | 2.611 | 1.451 |
| (-0.616, 2.142) | (0.447, 4.775)c | (-0.442, 3.344) | |
| Log(HDL) for 2,4-D < LOD | -0.412 | -0.396 | -0.295 |
| (-0.558, -0.265)a | (-0.627, -0.165)a | (-0.508, -0.081)b | |
| Log(HDL) for 2,4-D ≥ 2,4-D | -0.600 | -1.076 | -0.657 |
| (-0.944, -0.257)a | (-1.605, -0.547)c | (-1.123, -0.191)b | |
| Log(urinary creatinine) | -0.009 | 0.015 | 0.001 |
| (-0.063, 0.044) | (-0.067, 0.098) | (-0.078, 0.080) | |
| Gender | -0.093 | -0.087 | -0.044 |
| (-0.170, -0.016)c | (-0.203, 0.030) | (-0.160, 0.071) | |
| Age (years) | 0.001 | 0.002 | 0.002 |
| (-0.003, 0.004) | (-0.004, 0.007) | (-0.003, 0.007) | |
| Non-Hispanic Black | 0.171 | 0.183 | 0.175 |
| (0.082, 0.259)a | (0.047, 0.319)b | (0.046, 0.303)b | |
| Mexican American | 0.096 | 0.087 | 0.129 |
| (0.004, 0.188)c | (-0.059, 0.234) | (-0.017, 0.274) | |
| Other ethnicity | 0.232 | 0.074 | 0.131 |
| (0.017, 0.447)c | (-0.228, 0.376) | (-0.175, 0.437) | |
| Past smoker | -0.023 | -0.046 | 0.031 |
| (-0.120, 0.074) | (-0.188, 0.096) | (-0.107, 0.168) | |
| Active smoker | -0.112 | -0.186 | -0.064 |
| (-0.192, -0.033)b | (-0.307, -0.066)b | (-0.182, 0.054) | |
| BMI 25-29 kg/m2 | 0.310 | 0.325 | 0.368 |
| (0.228, 0.392)a | (0.197, 0.453)a | (0.249, 0.486)a | |
| BMI ≥ 30 kg/m2 | 0.687 | 0.672 | 0.795 |
| (0.590, 0.785)a | (0.533, 0.811)a | (0.648, 0.943)a | |
| Alcohol consumption | -0.081 | -0.089 | -0.052 |
| (-0.209, 0.046) | (-0.275, 0.097) | (-0.213, 0.109) | |
| Income ≥ 20K (%) | -0.045 | -0.013 | 0.004 |
| (-0.119, 0.030) | (-0.123, 0.096) | (-0.108, 0.116) | |
| Hours of fasting | -0.008 | -0.007 | -0.010 |
| (-0.016, 0.000)c | (-0.018, 0.005) | (-0.021, 0.002) | |
a p ≤ 0.001, b p ≤ 0.01, c p ≤ 0.05
P-values for the interaction term log(HDL)*2,4-D are 0.30 for all subjects, 0.02 for subjects with HbA1c > 5.1%, and 0.15 for subjects with T4 ≤ 8.5 μg/dl.