Figure 1 Rankin outcomes by time to IA therapy

mRankin 0–2 outcomes according to time to IA therapy (patterned bars) are depicted for a pre-IMS registry, IMS I, and IMS II. For subjects with NIH Stroke Scale score 10 or greater who were less than 81 years old, and who were treated intra-arterially after 3 hours, mRankin 0–2 outcomes in multicenter IV-IA trials have not differed significantly from those achieved in patients of similar age and stroke severity treated with IV rt-PA within 3 hours in the NINDS rt-PA trial (depicted as white bar). IA = intra-arterial; IMS = Interventional Management of Stroke; mRankin = modified Rankin score; NINDS = National Institute of Neurological Disorders and Stroke; rt-PA = recombinant tissue-type plasminogen activator.