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N4BP1 accumulates at PML NBs in SENP1-mutant MEFs. SENP1-mutant MEFs were examined by indirect immunofluorescence using anti-N4BP1 (A,C,D,F), anti-fibrillarin (B,C) and anti-PML (E,F), as labeled in each panel. (A-C) There is an increase in the level of N4BP1 outside of the nucleolus compared to wild-type MEFs (arrows point to non-nucleolar N4BP1). (D-F) There is a comparable increase in the colocalization of N4BP1 with PML (arrows point to co-localized N4BP1 and PML).
