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. 2010 Mar 23;123(8):1285–1294. doi: 10.1242/jcs.063321

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Fig. 1. — Dox-inducible expression of ΔE3β-catenin in corneal epithelium. (A,B) When compared with non-induced age-matched mouse with normal looking corneal surface (A), K12^rtTA/Wt/tetO-Cre/Ctnnb1^floxEx3/Wt triple-transgenic mice treated with Dox from E14.5 through P21 exhibited corneal epithelial hyperplasia (B). (C) Western blotting revealed that wild-type β-catenin (94-kD band) appeared in both lanes; however, ΔE3β-catenin (66-kD band) was only detected in Dox-treated (lane 2) K12^rtTA/Wt/tetO-Cre/Ctnnb1^floxE3/Wt mice. The 42-kD band corresponding to β-actin served as the loading control.