Table II.

Key Measurements on CLL Blood Samples, Before, During and After RTX Infusion

	Before treatment	After 30 mg	After 375 mg/m2
Normalized lymphocyte count	Higha 100%	Low 20%	Intermediate 60%
Plasma RTX concentration	0	1–5 ug/ml	>100 ug/ml
CH50	Normal	Normal	Depleted (10–90%)
CD20/cell, normalized	100	2–10	2–10
C3 fragments deposited	No	Yes	Yes

^aPretreatments levels varied from 5,000–100,000 lymphocytes/uL.¹⁵,¹⁷