Table 2.
SNPs showing the highest evidence of association in the COL22A1 gene (chromosome 8).#
| study | name | position | Genotype (Ref. All.) | Ref. All. Freq. | n | Beta* | SE | p value** |
|---|---|---|---|---|---|---|---|---|
| EUROSPAN | rs4075073 | 139808143 | A/C (A) | 0.37 | 3996 | 0.0671 | 0.0203 | 9.8 × 10-4 |
| EUROSPAN | rs4588898 | 139815390 | A/G (A) | 0.30 | 3999 | 0.0786 | 0.0212 | 2.1 × 10-4 |
| EUROSPAN | rs13255079 | 139828786 | C/T (T) | 0.16 | 4001 | 0.0769 | 0.0263 | 3.4 × 10-3 |
| EUROSPAN | rs9324496 | 139833578 | C/T (T) | 0.34 | 3995 | 0.0716 | 0.0205 | 4.6 × 10-4 |
| EUROSPAN | rs7824025 | 139839898 | A/C (A) | 0.07 | 3998 | 0.0762 | 0.0374 | 0.0414 |
| EUROSPAN | rs2873682 | 139840693 | A/G (A) | 0.30 | 2610 | 0.0915 | 0.0264 | 5.2 × 10-4 |
| EUROSPAN | rs11166844 | 139848062 | C/T (C) | 0.39 | 3993 | 0.0485 | 0.0202 | 0.0166 |
| EUROSPAN | rs1574172 | 139941802 | A/G (A) | 0.14 | 3998 | -0.0713 | 0.0284 | 0.0122 |
| EUROSPAN | rs4736078 | 139944298 | C/T (C) | 0.22 | 3996 | -0.0503 | 0.0242 | 0.0373 |
| EUROSPAN | rs6986041 | 139988449 | C/T (C) | 0.35 | 3936 | -0.0583 | 0.0207 | 4.8 × 10-3 |
| POPGEN | rs4282617 | 139795530 | C/G (C) | 0.25 | 1139 | -0.0822 | 0.0398 | 0.0391 |
| POPGEN | rs10092896 | 139856976 | C/T (C) | 0.27 | 1139 | -0.1123 | 0.0380 | 3.1 × 10-3 |
| POPGEN | rs2318334 | 139859320 | C/T (C) | 0.25 | 1140 | -0.1115 | 0.0390 | 4.2 × 10-3 |
| POPGEN | rs1574370 | 139866164 | A/G (A) | 0.24 | 1126 | -0.0992 | 0.0402 | 0.0137 |
| POPGEN | rs6991720 | 139871695 | C/G (G) | 0.25 | 1139 | -0.1074 | 0.0391 | 6.1 × 10-3 |
| POPGEN | rs7837787 | 139875897 | A/G (G) | 0.25 | 1140 | -0.1106 | 0.0391 | 4.7 × 10-3 |
| POPGEN | rs12155960 | 139886087 | A/G (G) | 0.26 | 1134 | -0.1152 | 0.0388 | 3.0 × 10-3 |
| POPGEN | rs11779129 | 139888085 | A/C (A) | 0.25 | 1140 | -0.0992 | 0.0388 | 0.0105 |
| POPGEN | rs16893541 | 139890024 | C/G (C) | 0.27 | 1124 | -0.1089 | 0.0390 | 5.2 × 10-3 |
| POPGEN | rs12549194 | 139896019 | A/C (C) | 0.26 | 1137 | -0.0830 | 0.0388 | 0.0327 |
| POPGEN | rs10093925 | 139904787 | C/T (T) | 0.36 | 1124 | -0.0687 | 0.0347 | 0.0478 |
| POPGEN | rs6577953 | 139914021 | C/G (C) | 0.40 | 1139 | -0.1032 | 0.0336 | 2.1 × 10-3 |
| POPGEN | rs6993839 | 139914702 | A/G (G) | 0.39 | 1131 | -0.1029 | 0.0342 | 2.6 × 10-3 |
| POPGEN | rs9650564 | 139918011 | C/T (C) | 0.41 | 1139 | -0.1017 | 0.0338 | 2.6 × 10-3 |
| POPGEN | rs9650565 | 139918089 | C/T (C) | 0.41 | 1133 | -0.0944 | 0.0339 | 5.3 × 10-3 |
| POPGEN | rs7014497 | 139923457 | C/T (C) | 0.39 | 1133 | -0.0892 | 0.0341 | 8.9 × 10-3 |
| POPGEN | rs9650566 | 139923872 | A/G (G) | 0.46 | 1139 | -0.1054 | 0.0332 | 1.5 × 10-3 |
| POPGEN | rs17740495 | 139941879 | C/T (C) | 0.08 | 1136 | 0.1393 | 0.0603 | 0.0209 |
| POPGEN | rs16893545 | 139948143 | A/C (C) | 0.18 | 1140 | 0.0953 | 0.0440 | 0.0304 |
| KORCULA | rs4076439 | 139690550 | A/G (G) | 0.25 | 895 | 0.0907 | 0.0393 | 0.0209 |
| KORCULA | rs4341165 | 139692067 | C/T (C) | 0.25 | 895 | 0.0907 | 0.0393 | 0.0209 |
| KORCULA | rs4909439 | 139727929 | C/T (C) | 0.17 | 895 | 0.1080 | 0.0518 | 0.0371 |
| KORCULA | rs3923549 | 139732799 | C/T (T) | 0.10 | 895 | 0.1513 | 0.0704 | 0.0316 |
| KORCULA | rs4073446 | 139735056 | C/T (T) | 0.11 | 895 | 0.1555 | 0.0658 | 0.0182 |
| KORCULA | rs7839680 | 139762863 | A/G (A) | 0.18 | 895 | 0.0950 | 0.0472 | 0.0440 |
| KORCULA | rs4909444 | 139770391 | G/T (T) | 0.38 | 895 | 0.0623 | 0.0289 | 0.0309 |
| KORCULA | rs4074052 | 139785008 | C/T (T) | 0.46 | 894 | -0.0504 | 0.0248 | 0.0419 |
| KORCULA | rs10112806 | 139806115 | A/C (C) | 0.41 | 895 | -0.0589 | 0.0280 | 0.0357 |
| KORCULA | rs1320279 | 139899978 | C/T (C) | 0.11 | 895 | -0.1823 | 0.0662 | 5.9 × 10-3 |
| KORCULA | rs2318345 | 139970360 | C/T (C) | 0.09 | 894 | 0.1755 | 0.0720 | 0.0147 |
# association models were adjusted for age and sex; *in standard deviations; **p value: for EUROSPAN, the p value refers to the meta-analysis of the five individual GWA studies, for popgen and Korcula, the p value is from the linear regression analysis (for details, see Methods).