Table 1.
Demographic, clinical and genetic characteristics of patients with AD and controls
| Characteristic | AD patients (n = 452) | Controls (n = 234) | P-value |
|---|---|---|---|
| Sex, f/m (%) | 299/153 (66.2/33.8) | 127/89 (58.8/41.2) | 0.071* |
| n = 452 | n = 216 | ||
| Age, years, | 76.2 ± 6.4 (60-102) | 75.9 ± 7.1 (65-94) | 0.215† |
| Mean ± SD (range) | n = 341 | n = 216 | |
| MMSE score, Median (25th -- 75th percentiles) | 22 (19-25) n = 367 | 29 (29-30) n = 113 | <0.001‡ |
| T-tau (pg/ml), Mean ± SD | 621 ± 319 n = 260 | 376 ± 162 n = 117 | <0.001† |
| P-tau181 (pg/ml), Mean ± SD | 76.9 ± 31.2 n = 260 | 63.3 ± 19.9 n = 91 | <0.001† |
| Aβ1-42 (pg/ml), Mean ± SD | 409 ± 100 n = 260 | 720 ± 200 n = 117 | <0.001† |
| SPs and NFTs score, Median (25th -- 75thpercentiles) | 7 (6-8.5) n = 65 | 1 (0-3) n = 80 | <0.001† |
|
APOE ε4 allele-carriers n (%) number of ε4 alleles: |
|||
| 0 | 128 (28.3) | 156 (72.2) | <0.001* |
| 1 | 238 (52.7) | 55 (25.5) | <0.001* |
| 2 | 86 (19.0) | 5 (2.3) | <0.001* |
| n = 452 | n = 216 |
*Fisher's Exact Test, †Mann-Whitney U-test. AD = Alzheimer's disease, SD = Standard Deviation, MMSE = Mini Mental State Examination, Aβ = β-amyloid, SPs = senile plaques, NFTs = neurofibrillary tangles