Table 2.
Ipsilateral | Contralateral | ||||
---|---|---|---|---|---|
Functional group | mRNA | Vehicle† | Levetiracetam† | % reduction | % reduction |
Egr3/Pilot | 6.9 ± 0.4 | 2.4 ± 0.2 | 66 | 69 | |
Transcription factors | c-fos | 5.8 ± 0.7 | 1.3 ± 0.1 | 77 | 67 |
Egr2/krox-20 | 12.5 ± 0.7 | 3.1 ± 0.2 | 75 | 88 | |
NGF | 1.4 ± 0.1 | 0.8 ± 0 | 45 | 9 | |
Neurotrophic factors | BDNF | 7.4 ± 0.8 | 2.4 ± 0.1 | 67 | 70 |
NT-3 | 0.7 ± 0 | 0.9 ± 0.1 | -22 | -31 | |
TGF-β | β-A activin | 13.1 ± 1.1 | 3 ± 0.1 | 77 | 89 |
superfamily | TIEG1 | 6.2 ± 0.5 | 1.5 ± 0.1 | 76 | 72 |
Inflammatory | TNF-α | 4 ± 0.3 | 1.1 ± 0.1 | 74 | 54 |
response | Cox-2 | 7.6 ± 0.5 | 2 ± 0.1 | 74 | 83 |
Homer-1a | 10.6 ± 1 | 2.9 ± 0.2 | 73 | 77 | |
GPCR interactions | Ania-3 | 3.2 ± 0.2 | 2.5 ± 0.1 | 21 | 32 |
RGS-2 | 3.2 ± 0.1 | 0.8 ± 0.1 | 73 | 61 | |
Extracellular | MMP-9 | 6.7 ± 0.3 | 2.2 ± 0.2 | 67 | 59 |
proteins | Narp | 20.5 ± 1.8 | 2.5 ± 0.1 | 88 | 90 |
Cell adhesion | Protocadherin-8 | 5.1 ± 0.3 | 1.1 ± 0.1 | 78 | 80 |
proteins | Arc | 15.9 ± 1.7 | 2.9 ± 0.1 | 82 | 78 |
Synaptopodin | 2.1 ± 0.2 | 1.4 ± 0.1 | 33 | 38 | |
Others | Pim-1 kinase | 4.3 ± 0.2 | 1.3 ± 0 | 70 | 71 |
GAPDH | 1.2 ± 0.1 | 0.9 ± 0 | 22 | 14 |
† relative expression ± SEM to control start normalized to β-actin