Figure 7.
General framework for GRN reconstruction. Detailed schematic description of the three-stage process we propose for determining the regulators of each one of an initial population of No genes. As we can depict in the first stage of the process (column 1) N-1 ENFRN structures are created for each one of the N genes. Sequentially combinations of the best NB regulators are tested for the output gene. Finally using phases 2 and 3 of the ENFRN, we fully train the ENFRN networks (column 3) the best sets of regulators for each one of the output (target) genes.