Table 1 .
Role of cardiac magnetic resonance in hypertrophic cardiomyopathy.
| Cardiomyopathy | Author | Year | Design | n | Description | |
|---|---|---|---|---|---|---|
| HCM, familial | Choudhury18 | 2002 | SC, P, C | 21 | Patchy LGE mainly located at insertion points was observed in 81% (17/21) of familial HCM patients and related to LV wall thickness. This finding may help to differentiate familial HCM from other forms of HCM | |
| Moon20 | 2003 | SC, P, C | 53 | The extent of LGE in HCM patients with ≥2 clinical risk factors for sudden cardiac death was higher than in patients with <2 clinical risk factors, especially when <40 years | ||
| Teroaka19 | 2004 | SC, P, C | 59 | HCM patients with ventricular arrhythmias on 24-hour Holter monitoring (14/59) had more extensive LGE than HCM patients without ventricular arrhythmias (45/59) | ||
| Germans5 | 2006 | SC, P, C | 32 | Crypts were visible at inferior insertion point 80% (13/16) of HCM mutation carriers without hypertrophy and not in healthy volunteers, yielding a 100% PPV and 84% NPV for identifying HCM carriers | ||
| Adabag21 | 2008 | SC, P, C | 177 | In HCM patients with no or mild symptoms, the presence of LGE was associated with an increased likelihood and frequency of ventricular tachyarrhythmias on Holter | ||
| HCM, non-familial | ||||||
| Anderson-Fabry | Moon42 | 2003 | SC, P, C | 26 | Inferolateral ill-defined subendocardial pattern of LGE was present in 50% (13/26) of Anderson-Fabry patients and related to increased LV mass | |
| Amyloidosis | Maceira39 | 2005 | SC, P, C | 46 | Global subendocardial pattern of LGE was found in 67% (20/30) of cardiac amyloidosis patients, as diagnosed with echocardiography. These patients also had higher T1-weighted signal intensity of myocardium compared with hypertensive patients (16). A combination of T1 values and the presence of LGE yields a PPV of 97% and an NPV of at least 88% for diagnosing cardiac involvement in amyloidosis | |
| Maceira37 | 2008 | SC, P, L | 28 | The presence of LGE was not a predictor of mortality after 5 years, but the extent of cardiac amyloid burden was. This was determined by the difference between subendocardial and subepicardial T1-weighted signal intensity on CMR images | ||
| Athlete’s heart | Petersen2 | 2005 | SC, P, C | 120 | Maximum end-diastolic wall to volume ratio >0.15 mm∙m2∙ml–1 has 99% specificity to differentiate athlete’s heart from pathological hypertrophy |
Design=study design, n=patient number, SC=single centre, P=prospective, C=cross-sectional, LGE=late gadolinium enhancement, HCM=hypertrophic cardiomyopathy, LV=left ventricular,, PPV=positive predictive value, NPV=negative predictive value, L=longitudinal, CMR= cardiac magnetic resonance.