Table 1.
Characteristics of 7512 individuals initiating HAART in Themba Lethu Clinical Cohort from 1 April 2004 to 31 March 2007 by pulmonary tuberculosis (PTB) treatment status at baseline.
| Prevalent PTB (n = 1197) |
No PTB (n = 6315) |
p-value | |
|---|---|---|---|
| Female gender | 695 (58.1) | 4300 (68.1) | <0.0001 |
| Age (Median, IQR) | 35 (30-40) | 35 (31-42) | 0.0134 ‡ |
| African ethnicity | 1144 (95.6) | 6022 (95.4) | 0.7483 |
| Employment | <0.0001 | ||
| Employed, student, retired | 358 (29.9) | 2372 (37.6) | |
| Not employed or unknown | 760 (63.5) | 3460 (54.8) | |
| Missing | 79 (6.6) | 483 (7.7) | |
| BMI | <0.0001 | ||
| <18.5 | 393 (32.8) | 1041(16.5) | |
| 18.5-24.9 | 663 (55.4) | 3473 (55.0) | |
| 25.0-29.9 | 110 (9.2) | 1229 (19.5) | |
| ≥30 | 31 (2.6) | 572 (9.1) | |
| Hemoglobin | <0.0001 | ||
| Normal | 330 (27.6) | 3353 (53.1) | |
| Low | 864 (72.2) | 2881 (45.6) | |
| Missing | 3 (0.3) | 81 (1.3) | |
| CD4 count (cells/mm3) | |||
| Median (IQR) | 58 (22-116) | 94 (34-165) | <0.0001 ‡ |
| Mean (95% CI) | 78 (74-83) | 115 (112-118) | <0.0001 † |
| ≤50 | 501 (41.9) | 1865 (29.5) | <0.0001 |
| 51-100 | 271 (22.6) | 1152 (18.2) | |
| 101-200 | 284 (23.7) | 1981 (31.4) | |
| 201-350 | 44 (3.7) | 581 (9.2) | |
| >350 | 12 (1.0) | 183 (2.9) | |
| Missing | 85 (7.1) | 553 (8.8) | |
| WHO stage IV at baseline | 207 (17.3) | 548 (8.7) | <0.0001 |
| History of ART (any) | 11 (0.9) | 211 (3.3) | <0.0001 |
| Pregnant | 20 (1.7) | 552 (8.7) | <0.0001 |
| Peripheral neuropathy | 89 (7.4) | 231 (3.7) | <0.0001 |
| History ofPTB | 60 (5.0) | 796 (12.6) | <0.0001 |
| HAART regimen | |||
| Efavirenz-based | 1139 (95.2) | 5018 (79.5) | <0.0001 |
| Nevirapine-based | 36 (3.0) | 597 (9.5) | <0.0001 |
| Other | 22 (1.8) | 700 (11.1) | <0.0001 |
| Co-trimoxazole | 1067 (89.1) | 5615 (88.9) | 0.8205 |
Figures are expressed as number (% total), except where noted. P-values are 2-sided by chi-square test
†
t-test or
‡
Wilcoxon rank sum test. After adjustment for altitude, lower limit of normal hemoglobin is 12.35 g/dl for men; 11.35 g/dl for non-pregnant women; and 10.35 g/dl for pregnant women.