Box and whisker plot shows the median, interquartile range, outliers (°) and extreme values (*) of the evaluated abbreviated sampling strategy IMPDH AEC0–4 in patients (a) with and without acute rejection episode (NS), (b) with and without recurrent infections (NS), and (c) with and without gastrointestinal side-effects (P < 0.05). AEC, area under the enzyme activity curve; IMPDH, inosine monophosphate dehydrogenase