Table 3.
Population pharmacokinetic parameters of MMF
| Model final | ||
|---|---|---|
| Parameters | Final estimate | SE (%) |
| Lag time (h) | 0.215 | 37.9 |
| Absorption rate constant (h−1) Ka | 5.16 | 43.4 |
| Apparent central volume of distribution (l) V1/F | 22.3 | 22.6 |
| Apparent peripheral volume of distribution (l) V2/F | 250 Fixed | |
| Intercompartment clearance (l h−1) Q/F | 18.8 | 14.8 |
| Apparent oral clearance (l h−1) CL/F | ||
| CL/F =θ1 × (Weight/23.5) ×θ2 ×[1–θ3 × (Albumin/38.6)] | ||
| θ1 | 22.5 | 16.9 |
| θ2 | 0.753 | 11.2 |
| θ3 | 0.570 | 12.9 |
| Residual proportional | 44.6 | 9.4 |
| Interindividual variability | ||
| Lag time | 54.0 | 100.3 |
| V1/F | 79.9 | 67.6 |
| Q/F | 57.6 | 35.2 |
| CL/F | 22.0 | 42.6 |