Table 1.
Baseline Characteristics of 987 Individuals With Stable Coronary Heart Disease by Amino Terminal Fragment of the Prohormone Brain-Type Natriuretic Peptide (NT-proBNP) Quartile*
| NT-proBNP Quartiles, pg/mL |
|||||
|---|---|---|---|---|---|
| 1 (8.06–73.95) (n = 247) | 2 (74–174.5) (n = 247) | 3 (175.1–459) (n = 247) | 4 (≥460) (n = 246) | P Value† | |
| Age, mean (SD), y | 61 (10) | 67 (10) | 68 (10) | 72 (11) | <.001 |
| Men | 197 (80) | 210 (85) | 188 (76) | 209 (85) | .03 |
| Race/ethnicity | |||||
| White | 133 (54) | 143 (58) | 154 (62) | 165 (67) | .02 |
| Black | 52 (21) | 39 (16) | 30 (12) | 39 (16) | .06 |
| Other | 62 (25) | 64 (26) | 63 (26) | 42 (17) | .06 |
| Medical history | |||||
| Myocardial infarction | 114 (47) | 118 (48) | 135 (55) | 160 (66) | <.001 |
| Stroke | 24 (10) | 30 (12) | 43 (17) | 43 (17) | .03 |
| Heart failure | 19 (8) | 26 (11) | 52 (21) | 76 (31) | <.001 |
| Diabetes | 57 (23) | 56 (23) | 66 (27) | 80 (33) | .05 |
| Revascularization | 122 (50) | 146 (59) | 146 (59) | 164 (67) | .002 |
| Current smoking | 64 (26) | 44 (18) | 49 (20) | 39 (16) | .03 |
| Measurement | |||||
| Systolic BP, mean (SD), mm Hg | 129 (17) | 131 (20) | 134 (21) | 137 (25) | <.001 |
| Cholesterol, mean (SD), mg/dL | |||||
| Total | 184 (42) | 178 (40) | 179 (43) | 171 (45) | .01 |
| Low-density lipoprotein | 109 (32) | 104 (34) | 104 (34) | 101 (35) | .03 |
| High-density lipoprotein | 45 (13) | 46 (13) | 46 (15) | 45 (15) | .90 |
| Creatinine clearance, mean (SD), mL/min | 99 (27) | 86 (26) | 77 (24) | 61 (24) | <.001 |
| <60 mL/min | 14 (6) | 35 (15) | 58 (25) | 122 (54) | <.001 |
| Current medication use | |||||
| β-Blocker | 100 (40) | 142 (57) | 160 (65) | 165 (67) | <.001 |
| ACE inhibitor | 91 (37) | 113 (46) | 138 (56) | 163 (66) | <.001 |
| Aspirin | 192 (78) | 200 (81) | 199 (81) | 171 (70) | .008 |
| Statin | 143 (58) | 169 (68) | 167 (68) | 154 (63) | .05 |
Abbreviations: ACE, angiotensin-converting enzyme; BP, blood pressure.
SI conversion factor: To convert total, low-density lipoprotein, and high-density lipoprotein cholesterol to mmol/L, multiply by 0.0259.
*
Values are expressed as number (percentage) unless otherwise indicated.
†
Analysis of variance was used for continuous variables and the χ2 test was used for categorical variables.