Figure 3.

A network of circadian clocks regulates vascular function. The master oscillator in the suprachiasmatic nucleus (SCN) stimulates the release of glucocorticoids and catecholamines by the adrenal glands. Two pathways mediate the stimulation of the adrenals. The first involves activation of the pituitary and the second the autonomic nervous system. Glucocorticoids and catecholamines exert pleiotropic effects on the vasculature including the synchronization of the vascular oscillator. Oscillators, not only in SCN, but also in pituitary and adrenals participate in the regulation of glucocorticoid and catecholamine oscillations. ATCH: adrenocorticotropic hormone