Table 1.
Effects of IH90s on PP2A, PKA and CaMKII Activities in the Rat Dorsal and Ventral Medullary Brainstem Regions
| |
PP2A activity* (μmol/min/mg) |
PKA activity (ng of active PKA/mg) |
CaMKII activity (ng of activeCaMKII/mg) |
|||
|---|---|---|---|---|---|---|
| Gas challenge | Dorsal medulla | Ventral medulla | Dorsal medulla | Ventral medulla | Dorsal medulla | Ventral medulla |
| Control (NOR) | 0.34 ± 0.08 | 0.22 ± 0.02 | 0.6 ± 0.2 | 0.4 ± 0.1 | 5.4 ± 0.3 | 5.8 ± 0.4 |
| IH90s | 0.31 ± 0.11 (n.s.) | 0.21 ± 0.04 (n.s.) | 0.7 ± 0.3 (n.s.) | 0.5 ± 0.4 (n.s.) | 6.1 ± 0.6 (n.s.) | 5.3 ± 0.5 (n.s.) |
*
Okadaic (2nM) acid inhibitable; All measurements were made in triplicate and average data are shown as mean ± S.E. (n = 7 rats in each group). n.s.-not significant, p > 0.05.