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. 2009 Aug;11(8):1945–1959. doi: 10.1089/ars.2009.2439

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Copyright 2009, Mary Ann Liebert, Inc.

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FIG. 2. — Summary of functional changes observed in a swine model of hypercholesterolemia and chronic myocardial ischemia. Hypercholesterolemic (HCHO) swine had impaired microvessel relaxation to (A) adenosine diphosphate (ADP), (B) vascular endothelial growth factor (VEGF), and (C) sodium nitroprusside (SNP) compared with normocholesterolemic controls (NORM). HCHO animals had reduced collateral-dependent perfusion (D) and reduced microvessel density (E), indicating impaired angiogenesis. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article at www.liebertonline.com/ars).