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(A) Schematic of proangiogenic signaling pathway, and (B) expression, and (C) quantification of proangiogenic mediators. Diabetic swine demonstrated reduced VEGF, Tie-2, and phospho-eNOS expression. Expression of antiangiogenic proteins, angiostatin (D), and endostatin (E) was significantly elevated in diabetic swine. VEGF, vascular endothelial growth factor; Ang-1, angiopoietin-1; eNOS, endothelial nitric oxide synthase.
