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. 2010 Apr 1;5(4):e9948. doi: 10.1371/journal.pone.0009948

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Singh et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Combination Index (CI) values were determined for a mutually exclusive interaction using CalcuSyn program, where CI <1 indicates synergism, CI = 1 indicates additive effect, and CI >1 indicates antagonism. Weighted average CI value (CI_wt) was assigned as [CI₅₀ + 2CI₇₅ + 3CI₉₀ + 4CI₉₅]/10. RAL, raltegravir; TDF, tenofovir disoproxil fumarate; ZDV, zidovudine.